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Leucyl-tRNA synthetase

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  • Inhibitors & Agonists
    14
    TargetMol | Inhibitors_Agonists
  • Natural Products
    1
    TargetMol | Natural_Products
LeuRS-IN-1
T387751364914-72-6In house
LeuRS-IN-1 is an orally active and potent Mycobacterium tuberculosis leucyl-tRNA synthetase inhibitor with anti-leukemic and anti-malarial activity, inhibits M.tb LeuRS, inhibits HepG2 protein synthesis, and can be used in leukemia research.
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LeuRS-IN-1 hydrochloride
T387731364683-67-9
LeuRS-IN-1 hydrochloride is an orally active and highly potent inhibitor of Mycobacterium tuberculosis leucyl-tRNA synthetase with anti-leukemic activity and anti-malarial activity, inhibits M.tb LeuRS, inhibits HepG2 protein synthesis, and can be used in the study of leukemia.
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10-14 weeks
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Ganfeborole HCl
GSK3036656 HCl, GSK656 HCl
T114972131798-13-3
Ganfeborole HCl (GSK3036656 HCl) is a small molecule compound with anti-tuberculosis activity and is an inhibitor of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS; IC50: 0.2 μM).
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8-10 weeks
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Leu-AMS
T11840288591-93-5
Leu-AMS, a leucine analogue and potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, exhibits cytotoxic effects in both cancer and normal cells and hampers bacterial growth. It specifically inhibits LRS's catalytic activity without impacting the leucine-induced activation of mTORC1.
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6-8 weeks
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Leu-AMS R enantiomer
T118412580391-91-7
Leu-AMS (R enantiomer) is the R enantiomer of Leu-AMS, a potent leucyl-tRNA synthetase (LRS) inhibitor that inhibits bacterial growth.
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3-6 months
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DS86760016
T392961853176-89-2
DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Notably, DS86760016 effectively inhibits LeuRS enzymes derived from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, exhibiting IC50 values of 0.38 μM, 0.62 μM, and 0.16 μM, respectively.
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Epetraborole hydrochloride
GSK2251052 hydrochloride
T40451234563-16-6
Epetraborole hydrochloride (GSK2251052 hydrochloride) is a potent and selective leucyl-tRNA synthetase inhibitor.
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TargetMol | Inhibitor Sale
GSK-3036656 free base
GSK-656 free base, GSK656 free base, GSK 656 free base, GSK 3036656 free base
T604052131798-12-2
GSK656 (GSK3036656) shows potent inhibition of Mycobacterium tuberculosis (Mtb) leucyl-tRNA synthetase (LeuRS) (IC50 = 0.20 μM) which has potential for the treatment of tuberculosis [1].
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10-14 weeks
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Epetraborole R-Mandelate
T711681234563-15-5
Epetraborole R-Mandelate is a potent and selective leucyl-tRNA synthetase inhibitor.
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1-2 weeks
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Epetraborole
T714581093643-37-8
Epetraborole is a potent and selective leucyl-tRNA synthetase inhibitor. Epetraborole was in development for the treatment of infections caused by multidrug-resistant Gram-negative pathogens.
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1-2 weeks
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LeuRS-IN-2
T88877
LeuRS-IN-2 (Compound 9) acts as an inhibitor of Wolbachia Leucyl-tRNA synthetase (LeuRS) in the presence of adenosine monophosphate (AMP), exhibiting an EC50 value of 6 nM and effectively inhibiting the growth of pathogenic hosts. It forms an adenosine adduct to hinder protein synthesis and shows promise in studies aimed at developing new antimicrobial agents targeting microbial communities.
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ML471
T891372226227-77-4
ML471 is an orally active parasitic leucyl-tRNA synthetase inhibitor useful for malaria research.
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10-14 weeks
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BC-LI-0186
4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide
T9533695207-56-8
BC-LI-0186 (4-(2,3-dimethyl-5-oxo-4-propan-2-ylpyrazol-1-yl)-N-(2-phenoxyethyl)benzenesulfonamide) is a potent and selective inhibitor of the interaction of Leucyl-tRNA synthetase (LRS) and Ras-related GTP-binding protein D (RagD) with IC50 of 46.11 nM. BC-LI-0186 competitively binds the RagD interaction site of LRS with Kd of 42.1 nM and has no effect on LRS-vps34, LRS-eprs, RagB-RagD association, mTORC1 complex formation. BC-LI-0186 potently inhibits the activity of tumor-associated MTOR mutants and the growth of rapamycin-resistant cancer cells. BC-LI-0186 can be used for lung cancer-related research.
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3,5-O-Dicaffeoylquinic acid
Isochlorogenic Acid A, (-)-3,5-Dicaffeoyl quinic acid, 3,5-Dicaffeoylquinic Acid
TL000589919-62-0
3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) is an isolated compound from Artemisia argyi; its ester derivatives exert anti-leucyl-tRNA synthetase of Giardia lamblia (GlLeuRS) and potential anti-giardial effects. 3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) as a neuraminidase inhibitory ligand in Flos Lonicerae, it has neuroprotective effects on SH-SY5Y cells and senescence-accelerated-prone mice 8 through the up-regulation of phosphoglycerate kinase-1. 3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) also has antioxidant and anti-complementary activities.
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